supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
supplement:
Acetylcysteine
drug:
Azathioprine
Research Papers that Mention the Interaction
“ N-Acetylcysteine reduced the AZA antiproliferative effect in both cell lines, and GST-M1 overexpression increased both superoxide anion production and cytotoxicity, especially in transfected HCEC cells.”
Role of oxidative stress mediated by glutathione-s-transferase in thiopurines' toxic effects.“In the IFIGENIA trial, the addition of oral NAC to corticosteroids and azathioprine was associated with a significantly smaller decline in the pulmonary function.”
“The inclusion of this faux placebo lead some, possibly correctly, to suggest that NAC was inhibiting the adverse effects of prednisolone and azathioprine , rather than possessing any direct antifibrotic effect.”
“Treatment with N-acetylcysteine (antioxydant) in association with corticosteroids and azathioprine may slightly reduce the rate of functional worsening.”
“The negative effects of azathioprine on the viability of hepatocytes were prevented by cotreatment with N-acetyl-l-cysteine.”
Azathioprine Acts upon Rat Hepatocyte Mitochondria and Stress-Activated Protein Kinases Leading to Necrosis: Protective Role of N-Acetyl-L-cysteine“ NAC significantly protected against the toxic effects produced by AZA.”
“Pretreatment with NAC prevented any change in the activities of both the aminotransferases after AZA.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback