supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
supplement:
Acetylcysteine
drug:
Artesunate
Research Papers that Mention the Interaction
“Combination with NAC reduced the parasitocidal effect of artesunate only within the first 6 h of incubation, whereas no interaction was observed with quinine.”
Suppressive effects of the anti-oxidant N-acetylcysteine on the anti-malarial activity of artesunate.“In the present study, Charunwatthana et al administered NAC 2 hours after the first dose of artesunate and measured parasitemia every 6 hours to see whether NAC would impair parasite killing by artesunate.”
“In vitro, the parasiticidal effect of artesunate is reduced when given simultaneously with NAC , but is unaffected when NAC is given 2 hours after artesunate (12).”
“The ROS scavenger N-acetylcysteine can significantly inhibit cell cycle arrest and apoptosis induced by ARS.”
Antimalarial agent artesunate induces G0/G1 cell cycle arrest and apoptosis via increasing intracellular ROS levels in normal liver cells
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback