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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
supplement:
Apigenin
Research Papers that Mention the Interaction
“ Apigenin induced ROS production in the L. amazonensis-infected macrophage, and the effects were reversed by NAC and GSH.”
Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action“As we presumed, treatment with apigenin was found to increase the level of intracellular reactive oxygen species (ROS), whereas pretreatment with antioxidants, N-acetyl-cysteine (NAC) or glutathione (GSH), completely attenuated ROS generation.”
“In addition, N-acetylcysteine reduced ROS production and improved ΔΨm loss and cell death that were caused by apigenin.”
Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells“The pro-apoptotic effect of apigenin was counteracted by RR and NAC pretreatment.”
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