Possible Interaction: Acetylcysteine and Antioxidants

“Upon initiation of therapy, we found that the group of patients undertaking NAC exhibited significant increase in GSH levels and in total antioxidant status while displaying substantial reduction in lipid peroxidation compared to the control group.”

“Likewise, quantification of … inhibitory effect of NAC on the frequency of micronuclei in mouth floor and in soft palate cells (1.… +/- 0.2; P = 0.001) and a stimulating effect of NAC on plasma antioxidant scavenging capacity (393 +/- 14 versus 473 +/- 19 … not on BAL fluid antioxidant scavenging capacity.”

“Notably, antioxidant N-acetylcysteine treatment influenced the microbial composition (decreased Rikenellaceae; increased Akkeransiaceae, Erysipelotrichaceae and Muribaculaceae) and attenuated the systemic autoimmunity in MRL/lpr mice.”

“Pre-treatment with antioxidant N-acetyl cysteine inhibited AA-induced cell death.”

“Pretreatment with the antioxidant NAC reduced IMQ-induced ROS production and attenuated IMQ-induced mitochondrial fission and mitophagy in skin cancer cells.”

“Pretreatment with the antioxidant N-acetyl-L-cysteine prevented SFN-induced apoptosis in CL1-0 cells and production of γH2AX in both CL1-0 and CL1-5 cells.”

“In addition, apoptosis and associated pathways were inhibited by the use of N‑acetyl‑L‑cysteine , an antioxidant that suppresses ROS production, indicating that the ROS generation triggered ER stress, mitochondrial dysfunction and downstream cascades that contributed to cell apoptosis.”

“Concurrent administration of the antioxidant N-acetyl-cysteine blocked the effects of high glucose on megalin expression.”

“Pre-treatment of the cells with the antioxidant N-acetyl-cysteine markedly suppressed T-2 toxin-induced neurotoxicity and caspase activation.”

“Consistently, our data revealed as well that mitigation of intracellular ROS levels with antioxidant NAC markedly attenuated H2O2-induced AMPK activation and ER stress.”