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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
supplement:
Andrographolide
Research Papers that Mention the Interaction
“At 24h, the addition of GSH or NAC had no effect on βNF-induced CYP1A1 mRNA expression, but significantly reduced the synergistic effect of Andro.”
“Glutathione (GSH) and N-acetyl-l-cysteine (NAC) significantly enhanced the βNF-induced expression, and partly reversed the suppressive effect of Andro in the early phase.”
Cellular glutathione content modulates the effect of andrographolide on β-naphthoflavone-induced CYP1A1 mRNA expression in mouse hepatocytes.“ N-acetyl cysteine prevented andrographolide-mediated DR5 induction and the apoptotic effect induced by the combination of rhTRAIL and andrographolide.”
Andrographolide induces apoptotic and non-apoptotic death and enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in gastric cancer cells.“ Andrographolide significantly induced reactive oxygen species (ROS) formation, p53 activation, Bax, and active caspase-3 expression, and these phenomena were suppressed by pretreating the cells with N-acetyl-L-cysteine , a ROS scavenger, or diphenylene iodonium, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) inhibitor.”
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