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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Acetylcysteine
drug:
Aminolevulinic Acid
Research Papers that Mention the Interaction
“In this study, we report that intracellular peroxides levels were … in HU‐treated murine erythroleukaemia (MEL) cells and that l‐acetyl‐N‐cysteine (LNAC), a potent reducing reagent, had a significant inhibitory … on the HU‐mediated induction of β‐globin, δ‐aminolaevulinate synthase mRNA expression and … of MEL cells.”
Oxidative stress is involved in hydroxyurea‐induced erythroid differentiation“When cells were incubated in the presence of ALA or succinylacetone methyl ester, N-acetylcysteine inhibited IRP1 activation, suggesting that the observed effect is mediated by an oxidative process.”
Haem precursor delta-aminolaevulinic acid induces activation of the cytosolic iron regulatory protein 1.
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