Possible Interaction: Acetylcysteine and Aminoglutethimide

“Pretreatment with N-acetylcysteine inhibited cytotoxicity and reactive oxygen species generation in CHANG and HepG2 cells exposed to rGO– Ag nanocomposite (50 µg/mL).”

“Ag NPs showed a robust antimicrobial activity against all tested pathogens and NAC substantially enhanced the antimicrobial activity of Ag NPs against all tested pathogens.”

“Synergism between Ag NPs and NAC has been confirmed by checkerboard assay.”

“The cytotoxic effect of Ag NPs alone and in combination with NAC was examined using human HepG2 cells and this revealed no cytotoxicity at MIC values of Ag NPs and interestingly, NAC reduced the cytotoxic effect of Ag NPs at concentrations higher than their MIC values.”

“Indeed, NAC reduced the binding of Ag to the soil, which probably was due to the formation of soluble but biologically unavailable Ag-cysteine complexes.”

“We previously demonstrated that N-acetylcysteine NAC ) could reduce the toxicity of silver ( Ag ) materials (nanoparticles (NPs) and Ag nitrate) to the soil invertebrate Enchytraeus crypticus (Oligochaeta).”

“The addition of NAC to the soil showed a remarkable reduction in the toxicity of Ag , indicating that NAC can act as a detoxifying agent for terrestrial organisms exposed to Ag materials.”

“Pre-incubation with N-acetyl-l-cysteine , an efficient antioxidant and Ag+ chelator, diminished the cytotoxicity caused by Ag NPs or Ag+ exposure.”