Possible Interaction: Acetylcysteine and Alpha-lipoic acid

“Hence, greater cysteine availability may explain much of the favorable impact of higher … intakes on mortality and frailty risk in the elderly, and joint supplementation with NAC and lipoic acid could be notably protective in the elderly, particularly in those who follow plant-based diets relatively low in protein.”

“The obtained results revealed that a cocktail of α-LA and NAC can drastically improve the genetic stability in FA lymphocytes in vitro, decreasing CI by 60% and 80% in cultures from FA patients and FA mosaic/chimera patients, respectively.”

“Phase 2 inducer nutraceuticals such as lipoic acid , administered in conjunction with N-acetylcysteine , have the potential to blunt the impact of oxidative stress by boosting myocardial levels of glutathione.”

“In contrast, several natural and synthetic reducing compounds (i.e., glutathione, dihydrolipoic acid, homocysteine, N-acetyl-L-cysteine , dithiothreitol, and non-thiol cell-impermeable reductant, tris-(2-carboxyethyl)phosphine), but not oxidized glutathione or alpha-lipoic acid effectively up-regulated the release of sTM in endothelial cells.”

“Furthermore, we observed that the protective effect of LA and NAC was more pronounced when both agents were present simultaneously.”

“A synthetic hybrid of lipoic acid and trolox or preincubation with N-acetylcysteine were less effective.”

“ ALA significantly increased ROS, and this effect was blocked by N-acetyl-cysteine , which also inhibited ALA-induced activation of p44/42 mitogen-activated protein kinase (MAPK) and AP-1, HO-1 expression, and HO activity.”