Possible Interaction: Acetylcysteine and Alkaline Phosphatase

“In patients treated with NAC , aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase ( ALP ) were significantly (P < 0.05) decreased after conditioning compared to their start values.”

“Additionally, dosing with N-acetylcysteine (NAC) effectively mitigated bone loss and normalized expression of ALP , Runx2, and OPN.”

“ NAC significantly reduced the levels of serum transaminase, ALP , bilirubin and liver weight and increased the levels of total protein, albumin and body weight.”

“ NAC prevented the AP prolongation in epicardial myocytes only (p < 0.05).”

“ NAC … alkaline phosphatase activity, mineral deposition and mRNA expression levels of osteogenesis markers collagen I, osteopontin, and signal pathway related protein Wingless-type family member 5a … droplets and the expression levels of lipoprotein lipase, fatty acid binding protein 4 and peroxisome proliferator-activated receptor gamma mRNA during adipogenic induction.”

“ N-acetyl cysteine completely prevented devastating suppression of alkaline-phosphatase activity and extracellular matrix mineralization in osteoblastic culture on scaffolds with bacterial co-incubation.”

“ NAC may have beneficial effects on AP through downregulation of the expression of MCP-1 and MIP-2.”

“ NAC (10–30 mM) enhanced alkaline phosphatase activity, mRNA expression of osteoblast differentiation‐associated genes and mineralized nodule formation.”

“ NAC improved some biochemical parameters (AST, alkaline phosphatase ) and oxidative stress parameters (malondialdehyde, luminol, glutathione) in the BDL model.”

“The antioxidants curcumin and N-acetylcysteine (NAC) decreased the activities of serum AST and ALP.”