Possible Interaction: Acetylcysteine and Aldesleukin

“ NAC caused an increase in the bcm of healthy persons with high plasma cystine/thiol ratios, and treatment of cancer patients with NAC plus interleukin-2 caused an increase in bcm, plasma albumin, and functional capacity.”

“ N-Acetylcysteine inhibited IL1-induced interleukin-2 in EL4, however, demonstrating that N-acetylcysteine was biologically active.”

“PEDF or NAC suppressed gene expression of interleukin-2 (IL-2) in Ang II-exposed MOLT-3 T cells.”

“N-acetyl cysteine NAC ) prevented oxidative stress-induced suppression of IL-2 biosynthesis, except for that induced by acute stress at 100 microM and above.”

“In contrast, NAC and GSH have no effect on IFN-γ production but increase IL-2 production as well as T cell proliferation.”

“In vitro, NAC and GSH have been shown to act on T cells by increasing IL-2 production, synthesis and turnover of IL-2 receptors, proliferation [3, 4] ‚ cytotoxic properties [5] and resistance to apoptosis [4].”

“ NAC and some other thiol antioxidants have also been reported to regulate the activation of some transcription factors involved in IL-2 production, such as NFκB and activator protein-1 transcription factors [6].”

“ IL-2 secreted by T cells was also enhanced by NAC , approximately 1.5-fold, but IL-2 secreted by cells from old donors was enhanced by 3-fold.”

“ IL-2 and NAc-cys were synergistic in increasing glutathione levels (reduced glutathione: 292% increase; total: 251% increase).”

“Incubation of splenocytes with NAc-cys (0.6 to 1.0 mM) resulted in significant changes in intracellular reduced and total glutathione (92% … markedly enhanced cell proliferation (threefold) and cytolytic effector cell generation (> fivefold increase in LU/10(6) cells) induced by the combination of NAc-cys … IL-2.”