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“Together with single-channel recordings, made to explore single pore-blocking events, we show that dissociation of ACh causes the gate to shut on a Zn2+ ion that effectively acts as a “foot in the door.””
The Journal of Biological Chemistry • 2010 | View Paper
“The transition metal ions Co2+, Mn2+, and Ni2+, but not the nontransition ions (Cd2+, Sn2+ and Zn2+ , markedly inhibited ACh and histamine relaxations in the aorta, whereas all metal ions antagonized KCI contractions.”