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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Yohimbine
Research Papers that Mention the Interaction
“Similarly to neuroleptic agents, yohimbine reduced striatal acetylcholine concentrations and counteracted the dopamine (10(-5) M)-induced inhibition of the potassium-evoked release of [3H]acetylcholine from slices of caudate nucleus.”
Antidopaminergic properties of yohimbine.“Atropine, pyrilamine, yohimbine and HOE 140 significantly reduced the vasodilator effect of acetylcholine , histamine, clonidine and bradykinin, respectively, but did not change the vasodilator effect of ASE.”
“The 5-HT1A agonist R-(+)-8-OH-DPAT and the α2-adrenoceptor antagonist yohimbine significantly increased ACh by about 100% and 50%, respectively.”
“Intraarterial infusion of norepinephrine reduced, but yohimbine increased both motor activity and dialysate ACh concentration, thereby indicating that the adrenergic neurons regulate the motor activity due to control of cholinergic neuronal activity.”
“In contrast, the alpha2 antagonist yohimbine (3 mg/kg) increased basal cortical acetylcholine release , thereby preventing meaningful investigation of its effects on tactile stimulation-evoked increases.”
“The response to ACh and adrenaline could be blocked by atropine (1 microM, 87 +/‐ 5%), yohimbine (1 microM, 73 +/‐ 8%), and to a lesser degree by prazosin (1 microM).”
“ Yohimbine prevented the clonidine effect and stimulated acetylcholine resting release.”
“ ACh blocked the ability of yohimbine , the presynaptic alpha receptor antagonist, to enhance the liberation of 3H-transmitter during field stimulation at 2 and 5 Hz, and it did so in all three of the test tissues.”
Presynaptic interactions between acetylcholine and adrenergic antagonists on norepinephrine release.“Combining acetylcholine with clonidine did not alter the inhibitory effect of clonidine but the combination of acetylcholine with yohimbine or idazoxan abolished the marked enhancing effects of yohimbine or idazoxan on S‐I efflux.”
“The inhibitory effects of clonidine and of NE on cortical ACh output are completely antagonized by yohimbine (0.28 mumol/kg), a selective alpha-2 antagonist, thus suggesting an involvement of the alpha-2 adrenoceptors in the neurochemical action of the drug.”
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