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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Tubocurarine
Research Papers that Mention the Interaction
“Inward currents were elicited by the application of acetylcholine (1-100 microM) and other agonists; these responses were blocked 65-97% by application of 10 microM d-tubocurare , confirming functional expression of human nicotinic receptors.”
Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.“4 Dihydro‐β‐erythroidine (DHBE) and tubocurarine antagonized both ACh and nicotine excitations but not those induced by glutamate or dl‐homocysteic acid.”
“ ACh (500 microM) responses were very effectively blocked by equimolar concentrations (100 microM) of the ganglionic antagonists d-tubocurarine , mecamylamine and hexamethonium.”
“Application of a somewhat larger quantity of DTC (about 4 x 10-10 C) produces a transient 50 % inhibition of the acetylcholine (or carbachol) potential.”
“The competitive blocking agents gallamine and tubocurarine antagonize the action of acetylcholine , whereas succinylcholine acts in the same way as an accumulation of acetylcholine, and its hydrolysis is similarly dependent upon the presence of cholinesterase, though at a slower rate (Bovet et al., 1951).”
“Peripheral nerves in the hindlimbs of rats and mice were cut and repaired, and various drugs were applied … either directly or via mini‐osmotic pumps over a 2–4‐week period to block the binding of acetylcholine to nicotinic …: α‐bungarotoxin, tubocurarine , atropine and, gallamine) and … P2Y receptors (suramin).”
Chemical communication between regenerating motor axons and Schwann cells in the growth pathway“ ACh markedly reduced or blocked and d‐tubocurarine augmented both pre‐ and postsynaptic field potentials, while α‐bungarotoxin and atropine were without effect.”
“ Tubocurarine (100 mumol/L) antagonized the inhibitory effect of ACh on I(K), and the drop of currents varied from the control value of (36.5+/-7..8)% to (16.9+/-13.8)% (n=8, P<0.01).”
“Responses to discreet applications of acetylcholine were reversibly blocked with tubocurare and reversibly eliminated in calcium-free Ringers.”
“Because of the competitive mechanism of action of tubocurarine , the rate of hydrolysis of acetylcholine at the neuromuscular junction may modulate its neuromuscular blocking effect.”
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