supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Thiamine
Research Papers that Mention the Interaction
“In vitro animal studies have suggested that thiamine is involved in the presynaptic release of acetylcholine.”
Evidence for a central cholinergic effect of high‐dose thiamine“ Thiamine is important not only in the metabolism of acetylcholine but also in its release from the presynaptic neuron.”
“BACKGROUND Perineural administration of thiamine , via axonal flow, could strenghthen synthesis of ACh in the dorsal horn inhibitory interneurons, thus potentiating analgesia.”
“ Thiamine itself is a pharmacologic antagonist of acetylcholine , which may explain the nerve lesions caused by thiamine deficiency.”
“Quaternary ammonium compounds, such as choline and acetylcholine significantly inhibited thiamine uptake in isolated rat hepatocytes.”
The inhibitory effect of choline and other quaternary ammonium compounds on thiamine transport in isolated rat hepatocytes.“Among quarternary ammonium compounds other than thiamine derivatives, choline and acetylcholine significantly inhibited thiamine uptake by rat liver cells, whereas betaine and carnitine did not.”
“From this and our previous work, it is proposed that thiamine is involved, directly or indirectly, in the process of ACh release.”
“In addition, related changes of the vitamin and the transmitter were observed under other conditions, suggesting a functional link between the metabolism of thiamine and that of ACh in cholinergic nerve terminals.”
“Abstract Thiamine interacts in vitro with acetylcholine , norepinephrine and serotonin yielding molecular complexes.”
The synaptolytic effect of thiamine related to its interaction with neurotransmitters.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback