Possible Interaction: Acetylcholine and Taurine

“The diminished relaxation response to ACh and EFS as well as diabetes‐related changes in expressions of these proteins in corpus cavernosum of diabetic rats was significantly improved by taurine.”

“ Taurine supplementation improved the relaxation response to acetylcholine and eNOS-derived NO production, increased EC-SOD and p-eNOS protein expression, as well as reduced ROS generation and p47phox expression in the aortas from LPT rats.”

“Norepinephrine-induced hyper-contractility as well as acetylcholine-induced , endothelium-dependent hypo-relaxation in diabetes were significantly prevented after taurine treatment.”

“Simultaneously, LOX-1 and ICAM-1 expression were enhanced in aortas of diabetic rats; whereas blunted endothelium-dependent vasodilator responses to acetylcholine , increased serum oxLDL and sICAM-1 level as well as overexpression of LOX-1 and ICAM-1 were all attenuated significantly by taurine treatment.”

“ Taurine decreases the depolarization-induced release of labelled norepinephrine and acetylcholine from rat cerebral cortex, possibly by increasing retention of Ca2+ within mitochondria (5).”

“ Taurine , when bath-applied to the sixth abdominal ganglion of the cockroach Periplaneta americana L. produced a reversible dose-dependent blockade of acetylcholine release determined by monitoring excitatory postsynaptic potentials (EPSPs) using the single-fibre oil-gap technique and mannitol-gap technique.”

“ Taurine applied to rats intracerebroventricularly in doses 0.1--3.0 mg increased ACh level and decreased ACh synthesis in the cerebral cortex.”

“ Taurine also inhibited the change by digitoxin of the responses to acetylcholine and ouabain but not to noradrenaline.”

“NO is known to have effects on the storage, uptake and/or release of neurotransmitters such as acetylcholine , dopamine, noradrenaline, GABA, glutamate, taurine and glycine in the central nervous system (CNS) (Bernstein et al., 2005).”