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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“S1P on its own did not relax or contract HCC strips, but on the other hand, incubation with S1P (0.1 μM) caused a 6-fold increase in relaxation induced by a subliminal dose of acetylcholine.”
Sphingosine 1-Phosphate Induces Endothelial Nitric-Oxide Synthase Activation through Phosphorylation in Human Corpus Cavernosum“However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.”
Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice.
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