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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Saponin
Research Papers that Mention the Interaction
“Treatment with saponin abolished the relaxation elicited by acetylcholine and A23187 but did not influence the response to nitroprusside and ATP.”
Effects of endothelial impairment by saponin on the responses to vasodilators and nitrergic nerve stimulation in isolated canine corpus cavernosum“Removal of the endothelium with saponin suppressed relaxation to acetylcholine and abolished the contractions produced by hypoxia.”
“Furthermore, the disruption of endothelium by perfusing the hearts with saponin abolished the vasoconstrictor effect of ACh but did not alter negative chronotropic and positive inotropic effect.”
“5 Similarly, after treatment with saponin , the increases in coronary flow in response to 5‐HT, ACh and substance P were reduced to 2.1 ± 0.3, 1.3 ± 0.3 and 0.4 ± 0.2 ml min−1 g−1, respectively (all P < 0.05).”
“6 L‐NAME and saponin also inhibited 5‐HT, ACh and substance P‐induced NO release (P < 0.05), without affecting equivalent responses to SNP.”
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