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Last Updated: 2 years ago

Possible Interaction: Acetylcholine and Saponin

supplement:

Saponin

Research Papers that Mention the Interaction

Treatment with saponin abolished the relaxation elicited by acetylcholine and A23187 but did not influence the response to nitroprusside and ATP.
British journal of pharmacology  •  1999  |  View Paper
Removal of the endothelium with saponin suppressed relaxation to acetylcholine and abolished the contractions produced by hypoxia.
European journal of pharmacology  •  1999  |  View Paper
Furthermore, the disruption of endothelium by perfusing the hearts with saponin abolished the vasoconstrictor effect of ACh but did not alter negative chronotropic and positive inotropic effect.
The Japanese journal of physiology  •  1998  |  View Paper
5 Similarly, after treatment with saponin , the increases in coronary flow in response to 5‐HT, ACh and substance P were reduced to 2.1 ± 0.3, 1.3 ± 0.3 and 0.4 ± 0.2 ml min−1 g−1, respectively (all P < 0.05).
6 L‐NAME and saponin also inhibited 5‐HT, ACh and substance P‐induced NO release (P < 0.05), without affecting equivalent responses to SNP.
British journal of pharmacology  •  1996  |  View Paper