Possible Interaction: Acetylcholine and Quercetin

“In separate studies, pretreatment with quercetin (100 μM) prevented force generation upon exposure to ACh.”

“2 … to acetylcholine (1 μm) were inhibited by the following lipoxygenase inhibitors, with the approximate IC50 values indicated in ….5 μm), nordi‐hydroguairetic acid (NDGA, 5 μm), AA 861 (20 μm), phenidone (30 μm), quercetin (40 μm), BW 755C (300 μm), and …); with cirsiliol 50% inhibition was not achieved.”

“The findings suggested that the synergistic properties of quercetin and acetylcholine enhance the antibacterial activity of SeNPs.”

“Thus, we can suggest that the quercetin is able to modulate NTPDase, ADA, AChE, and MPO activities and contribute to maintain the levels of ATP, adenosine, and acetylcholine normal , respectively, exhibiting potent pro-inflammatory and anti-inflammatory actions.”

“The influences of quercetin on the spontaneous contraction of small intestine and contraction induced by Ach , histamine and Bacl2 were observed and the mechanism of quercetin was studied.”

“The results showed that quercetin relaxed colon muscle strips in a concentration-dependent manner and antagonized the contractile effect of acetylcholine and neostigmine.”

“In the SHR tissues, however, quercetin or ascorbic acid significantly improved the relaxation responses to ACh and reduced the contractions to PE with greater potency for quercetin.”

“Results In SHR, quercetin reduced the increase in blood pressure and heart rate and enhanced the endothelium-dependent aortic vasodilation induced by acetylcholine , but had no effect on the endothelium-independent response induced by nitroprusside.”

“ Quercetin (1 and 5 μol/l) inhibited the effect of PGI2 and, at higher concentrations, it also caused partial depression of the responses to ACh.”

“Isorhamnetin, but not quercetin , also reduced the endothelium-dependent contractile responses induced by acetylcholine.”