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Last Updated: 2 years ago

Possible Interaction: Acetylcholine and Progesterone

Research Papers that Mention the Interaction

The lower esophageal sphincter dose-response curve to acetylcholine and gastrin was blunted by estradiol as well as progesterone ; progesterone was more effective in inhibiting the maximum response.
Annals of Internal Medicine  •  1993  |  View Paper
Acetylcholine significantly stimulated progesterone secretion by GCs in a dose-related manner.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology  •  1993  |  View Paper
Combined in vitro-in vivo studies have shown that progesterone inhibits acetylcholine sensitivity and therefore participates in the regulation of tubal motility.
Bibliotheca gynaecologica  •  1969  |  View Paper
In contrast to TCF, acetylcholine (0.1-100 microM) increased progesterone production.
Mutation research  •  2008  |  View Paper
In conclusion, pregnenolone and progesterone inhibited M1 and M3 receptor functions noncompetitively by the mechanism independent of PKC and by interfering with ACh binding to the receptors.
The inhibitory effects of pregnenolone and progesterone were overcome at higher concentrations of ACh.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2005  |  View Paper
The L‐NOARG‐resistant acetylcholine‐induced relaxation was inhibited by metyrapone, proadifen and 17‐octadecynoic acid, non‐selective cytochrome P450 mono‐oxygenase (CYP) inhibitors, and progesterone and ketoconazole, inhibitors selective to CYP3A.
British journal of pharmacology  •  1999  |  View Paper
Progesterone inhibited catecholamine secretion evoked by ACh , nicotine and oxotremorine-M in a dose-dependent manner with similar IC50 values in the microM range.
Neuropharmacology  •  1997  |  View Paper
In addition, we show that progesterone is not a competitive inhibitor but may interact with the acetylcholine binding site and that its effect is independent of the ionic permeability of the receptor.
Proceedings of the National Academy of Sciences of the United States of America  •  1992  |  View Paper
ACh between 10(-8)-10(-4) M … the secretion of oxytocin and progesterone , with an ED50 of 6.6 microM. Ascorbic acid (0.5 mM), a known stimulator of granulosa secretion, … of hormone secreted and a 7-fold increase in cellular sensitivity to ACh (ED50 = approximately 0.9 microM).
Endocrinology  •  1990  |  View Paper
Acetylcholine alone did not induce oocyte maturation, though it did accelerate maturation induced by progesterone.
Developmental biology  •  1988  |  View Paper
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