Possible Interaction: Acetylcholine and Potassium

“Addition of acetylcholine to the solution increases the loss of potassium.”

“The reduction in developed tension in segments contracted with potassium and relaxed with 1 microM acetylcholine was 65% (CL 47 to 83) in undistended, and 15% (CL -1 to 32) in distended (P < 0.01).”

“The cells release ACh spontaneously and this release is enhanced upon depolarization with potassium or veratridine (the latter effect is blocked by tetrodotoxin).”

“Depolarizing concentrations of potassium (16-63 mM) in the medium increased the rate of release of ACh.”

“The presence of acetylcholine in the muscle bath resulted in an augmentation of response to excess potassium.”

“Cholinergic and noradrenergic modulatory effects on granule cells were based on data obtained from slice experiments; specifically, ACh reduced the conductance densities of the potassium M current and the calcium-dependent potassium current, whereas NE nonmonotonically regulated the conductance density of an ohmic potassium current.”

“In the meantime, we have learned that the neurotransmitter acetylcholine acting through muscarinic M2 receptors activates cardiac potassium (Kir3) channels via the βγ subunits of G proteins, an important effect that contributes to slowing atrial pacemaker activity.”

“Both feeding and elevated potassium increased ACh release in the hippocampus.”

“In response to elevated potassium , E, and TAM significantly increased the percent change in ACh release.”

“However, release of glutamate and acetylcholine was decreased from the hippocampus in response to high‐potassium treatment in the Cyp D−/− mice than in the wild‐type mice.”

“The findings of our experiments can be explained by a direct action of acetylcholine on the Ca++ transmembrane transport, which does not appear to be at variance with the observation that acetylcholine increases the potassium membrane conductance.”