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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Acetylcholine
supplement:
Polypeptides
Research Papers that Mention the Interaction
“These polypeptides inhibit acetylcholine release at neuromuscular junctions, thus causing muscle paralysis involving both somatic and autonomic innervation.”
Botulinum Neurotoxin: The Ugly Duckling“c) Acetylcholine stimulated, in a dose-dependent manner, the secretion of PP from the isolated perfused porcine pancreas, half-maximal effective dose being 0.19 muM; maximal PP output in response to 5 min stimulation was 228 pmol, range 140-342 pmol, n = 5.”
“Administration of acetylcholine resulted in an elevation of plasma PP , whereas epinephrine induced no increase.”
Role of autonomic nervous system in the response of plasma pancreatic polypeptide to glycopenia in dogs.“Thus PP inhibits pancreatic enzyme secretion via presynaptic modulation of acetylcholine release.”
“Two-dimensional gel … chromaffin cells to acetylcholine produced two types of effect … kinase activities affecting about 30 polypeptides ; activation of protein phosphatase activities resulting in the dephosphorylation of about 40 polypeptides, most of them … the exception of the alpha-subunit of pyruvate dehydrogenase and the 20.4 kilodaltons polypeptide.”
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