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Last Updated: 2 years ago

Possible Interaction: Acetylcholine and Phosphatidic Acid

Research Papers that Mention the Interaction

In these smooth muscle tissues, ACh (above 10 nM) reduced the amount of phosphatidylinositol 4,5-bisphosphate (PI-P2) and dose dependently increased the amount of phosphatidic acid.
Circulation research  •  1987  |  View Paper
…,ACh (10−5 M) either reduced or increased the … phosphatidyl inositol 4,5‐biphosphate (PI‐P2) or phosphatidic acid (PA) in the lipid fraction of the smooth muscle cells to 60% or to 350% … the control value, respectively, thereby indicating that ACh stimulates the phosphodiesteric hydrolysis of PI‐P2.
British journal of pharmacology  •  1985  |  View Paper
In cultured bovine chromaffin cells, acetylcholine as well as muscarine stimulated the 32Pi incorporation into phosphatidic acid , induced Ca2+ mobilization across the cells, and, in parallel, elevated intracellular cyclic GMP content.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme  •  1984  |  View Paper
In cultured bovine chromaffin cells, acetylcholine as well as muscarine stimulated the 32Pi incorporation into phosphatidic acid , induced Ca2+ mobilization across the cells, and, in parallel, elevated intracellular cyclic GMP content.
Journal of neural transmission. Supplementum  •  1983  |  View Paper
In the absence of Ca++, 50 micrometer ACh increased TPI breakdown and phosphatidic acid (PA) labeling by 16 and 38%, respectively.
The Journal of pharmacology and experimental therapeutics  •  1978  |  View Paper
ACETYLCHOLINE stimulates the turnover of phosphatidylinositol (PI) and phosphatidic acid (PA) in brain in vitro and in vivo2,3.
Nature  •  1976  |  View Paper
The increase in the 32P labeling of PhA and PhI in the presence of norepinephrine or acetylcholine , which ranged from 2- to 6-fold, was found to be time- and concerntration-dependent.
Life sciences  •  1974  |  View Paper
At exogenous ACh concentrations of 10–5m and above, some ACh enters the synaptosomes by diffusion and significantly stimulates 32Pi incorporation into phosphatidic acid.
Journal of neurochemistry  •  1974  |  View Paper
Acetylcholine significantly increased the specific radioactivity of phosphatidic acid but had no effect on that of phosphatidylinositol or the nucleotide fraction.
Journal of neurochemistry  •  1972  |  View Paper
Smaller increases in turnover on stimulation with ACh were seen in phosphatidylethanolamine and in phosphatidic acid.
Annals of the New York Academy of Sciences  •  1969  |  View Paper
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