Possible Interaction: Acetylcholine and Niacin

“The released ACh binds back to nicotinic (nAChRs) and muscarinic receptors on lung cancer cells to accelerate their proliferation, migration and invasion.”

“In this way non‐neuronal ACh binds to the nicotinic or muscarinic receptors expressed on these local and migrating cells and modulates basic cells functions such as proliferation, differentiation, migration and the transport of ions and water.”

“Lung cancers express an autocrine cholinergic loop in which secreted acetylcholine can stimulate tumor growth through both nicotinic and muscarinic receptors.”

“ Acetylcholine has been shown to influence cell proliferation and neurite outgrowth through nicotinic and muscarinic receptor-mediated mechanisms and thus, that the expression of AChE and BChE at non-synaptic sites may be associated with a cholinergic function.”

“The currents elicited by ACh were effectively blocked by nicotinic antagonists, but not by the muscarinic antagonist atropine.”

“Excessive accumulation of acetylcholine leads to activation nicotinic and muscarinic acetylcholine receptors, these receptors activate diverse kind of cellular responses by distinct signaling pathways.”

“ ACh secreted by those cancers stimulates growth of the tumors by binding to nicotinic and muscarinic receptors expressed on lung cancers.”

“ ACh can interact specifically with macrophage α7 subunits of nicotinic ACh receptors, leading to cellular deactivation and inhibition of cytokine release.”

“ Nicotinamide decreased the toxicity of acetylcholine in rats, whil nikethamide did not.”

“In consequence of the impaired hydrolysis, the neurotransmitter acetylcholine accumulates in cholinergic synapses and disturbs functional activity of nicotinic and muscarinic acetylcholine receptors by overstimulation and subsequent desensitization.”