Possible Interaction: Acetylcholine and Methionine

“Forearm resistance vessel dilatation to acetylcholine was significantly impaired 7 hours after methionine (placebo, 583 +/- 87% vs methionine 30 +/- 68%; p <0.05).”

“Forearm resistance vessel dilatation to acetylcholine was significantly impaired 7 hours after methionine (methionine, 477+/-82%; placebo, 673+/-110%; P=0.016).”

“ ACh in concentrations of 5·10−3–10−2 M decreases the membrane potential; the simultaneously recorded action potentials initially display an increased amplitude and a marked prolongation and elevation of the descending phase which appears oscillatory.”

“After smoking, 10−5 M ACh constricted cerebral arterioles (−7.7±1.8%).”

“ Acetylcholine (10−5 M) caused a vasodilation in both veins that was endothelium-independent, and which was blocked by the soluble guanylyl cyclase inhibitor, ODQ ( 10−5 M).”

“ ACh , when applied at a concentration of 10−6 M , evoked a depolarization of the smooth muscle membrane which was slow in time course (slow depolarization).”

“ ACh at concentrations of 10−6–10−4 M decreased the maximum rate of rise of the action potential restored by isoproterenol or theophylline, but ACh (10−8–10−4 M) had no significant effect on the maximum rate of rise of the action potential restored by excess Ca2+.”

“The actions of ACh on electrial and mechanical responses restored by isoproterenol or theophylline were increased by physostigmine ( 10−7 M ) and were antagonized by atropine (10−7 M) but not by hexamethonium (3×10−4 M).”

“Stimulation with ACh concentrations varying from 10−8 to 10−5 M and with A23187 concentrations of 10−6 and 10−5 M caused parallel increases in cytosolic Ca2+ and Na+ ([Ca]i, [Na]i).”

“Diphenylhydantoin (DPH) 10−5 M ) inhibited the spontaneous as well as the acetylcholine (10−4 M)-induced release of CA.”

“In the isometric tension experiments, the methionine group had a significantly decreased (p < 0.01) vasodilatation reaction induced by acetylcholine , an endothelium-dependent vasodilator.”