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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Masoprocol
Research Papers that Mention the Interaction
“Endothelium-dependent relaxation in response to acetylcholine and A23187 was antagonized by nordihydroguaretic acid , a lipoxygenase inhibitor, and methylene blue and haemoglobin, inhibitors of soluble guanylate cyclase.”
Endothelium-dependent relaxation in isolated human arteries and veins.“In mesenteric arteries, NO- and COX-independent relaxations to ACh were inhibited by the lipoxygenase (LO) inhibitors nordihydroguaiaretic acid (NDGA; 10 μM) and BW-755C (200 μM), the K(+) channel inhibitor apamin (1 μM), and 60 mM KCl and eliminated by endothelium removal.”
Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries.“Release of ACh was stimulated by arachidonic acid; this release was partially depressed by nordihydroguaiaretic acid (NDGA), which inhibits lipoxygenase activity.”
“Responses to BAEE, BAME, L‐arginine hydrochloride, L‐alanine methylester and acetylcholine were similarly selectively reduced by NDGA (10 μM) pretreatment.”
“Administration of ETYA, NDGA , or HQ abrogated the observed vasodilatation to acetylcholine , which was not seen with vehicles alone (P less than 0.01).”
“In contrast, 5,8,11,14-eicosatetraynoic acid and nordihydroguaiaretic acid attenuated relaxation in response to leukotriene D4 and acetylcholine , suggesting that lipoxygenase-derived products may participate in leukotriene D4-induced as well as acetylcholine-induced relaxation.”
“ Nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, significantly reduced the dilator responses to ACh , A23187 and SP, but did not reduce the responses to sodium nitrite.”
“3 Gossypol (3 μm), metyrapone (10 μm) and nordihydroguaiaretic acid , (NDGA, 30 μm), presumed inhibitors of EDRF biosynthesis, reduced or abolished the response to acetylcholine and histamine in perfused kidney and mesentery of the rat without affecting vasodilatation due to nitroprusside.”
“The lipoxygenase-inhibitor nordihydroguaiaretic acid NDGA ), inhibited the responses to ACh and A23187, but did not reduce the responses to PGI2.”
“The responses to acetylcholine and vagal stimulation were reduced by quinacrine, p-bromophenacyl bromide and nordihydroguaiaretic acid , while indomethacin had no effect.”
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