Possible Interaction: Acetylcholine and Magnesium

“ Magnesium inhibits the release of acetylcholine from the motor nerve terminal and thus potentiates the action of the non-depolarizing neuromuscular blocking drugs.”

“ Magnesium is known to act at the neuromuscular junction by inhibiting the presynaptic release of acetylcholine and desensitizing the postsynaptic membrane.”

“If the fluid bathing the synapse is changed to one with a high concentration of magnesium , which reduces the release of acetylcholine , -conotoxin MII significantly decreases the tetanic ratio.”

“ Magnesium has a marked inhibitory effect on ACh release.”

“The antagonistic effect of Mg on calcium decreases the presynaptic release of acetylcholine at the neuromuscular junction and the release of epinephrine at the peripheral sympathetic nerves and the adrenals.”

“ Magnesium acts to antagonize the action of acetylcholine at the motor end plate of the neuromuscular junction and may operate synergistically with underlying neuromuscular disorders.”

“The main mechanism of paralysis induced by magnesium excess is the blocking of neuromuscular transmission due to the magnesium-indiced inhibition of acetylcholine release ”

“ Magnesium , like curarine, reduces the stimulating effect of acetylcholine on muscle; it prevents the contractions which follow local application of that substance to the end-plate region (Engbaek, 1948).”

“The removal of magnesium from the organ chamber solution impaired vasodilation in response to acetylcholine and adenosine diphosphate.”

“These results, employing two different forms of a fluorescent bioprobe for the measurement of magnesium, indicate that unlike histamine, CCK-8 and ACh can evoke marked changes in intracellular free magnesium concentration during the stimulus-secretion coupling process.”