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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Magnesium Cation
Research Papers that Mention the Interaction
“Phencyclidine (PCP) and … concentrations of Mg++ (1.2 mM) also inhibited ACh release evoked by L-glutamate, L-aspartate and DL-homocysteate, but not ACh release evoked by the glutamate analogs quisqualate and kainate, suggesting that PCP is selective for the magnesium-sensitive, NMDA-preferring glutamate-aspartate receptor subtype.”
Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.“The ACh release is diminished by Mg++.”
“4 Morphine, raised concentrations of Mg++ or reduced concentrations of Ca++ inhibited contractions produced by TMA and by acetylcholine to a similar extent.”
“Lowering the calcium or raising the magnesium concentration in the incubation medium reduced the release and synthesis of ACh and their enhancement by atropine.”
“Removal of Mg++ or increased Mg++ concentrations in the presence of normal Ca++ concentrations increased the release of ACh.”
“It is concluded that cocaine, procaine, cooling, reduction of calcium ion and increase of magnesium ion concentrations all reduce the spontaneous output of acetylcholine , which has its origin in the parasympathetic nerve-endings of the intramural nerve plexuses.”
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