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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Acetylcholine
supplement:
Leucine
Research Papers that Mention the Interaction
“In vitro studies revealed that SHR + L + S displayed a better relaxation response to acetylcholine than the untreated SHR and the SHR with monotherapy (P < 0.01).”
Functional and morphological improvement in erectile tissue of hypertensive rats by long-term combined therapy with phosphodiesterase type 5 inhibitor and losartan.“Furthermore, atropine blocked the effect of ACh and agonists suggesting that ACh reduces I(Ca, L ) through activation of muscarinic receptors.”
“Whole-cell voltage-clamp recordings from dissociated hair cells of the statocyst of octopus, Eledone cirrhosa, demonstrated that application of ACh , carbachol or muscarine (10 microM) reversibly decreased the amplitude of L-type calcium current (I(Ca, L )), while nicotine (10-100 microM) did not have any effect.”
“In hyperthyroid myocytes, acetylcholine (ACh) (1 μM) decreased ICa, L from −26.86±1.49 to −18.33±1.25 pA/pF (P<0.05), while in euthyroid myocytes ACh decreased ICa, L from −6.80±0.61 to −6.00±0.39 pA/pF (NS).”
“The depressing effect of ACh on ICa, L may occur via inhibition of the high basal adenylate cyclase activity leading to a decrease of cAMP-dependent protein kinase stimulation and thus to a dephosphorylation of calcium channels.”
“ISO (ISO-beta(1)/beta(2)-AR stimulation) increased I(Ca,L) and even though ISO releases NO, ACh prominently inhibited I(Ca, L).”
“When isoproterenol (ISO; 0.1 microM) plus the beta(2)-AR antagonist ICI 118,551 (ISO-beta(1)-AR … 0.1 microM fenoterol, a beta(2)-AR agonist (FEN-beta(2)-AR stimulation) increased I(Ca,L), ACh (1 microM) … I(Ca, L ) by -60 +/- 4 … -63 +/- 6 %, respectively.”
“BAPTA-stimulated ICa L was inhibited by acetylcholine and by the cAMP-dependent protein kinase (PKA) blocker H-89.”
“Withdrawal of a 2-minute exposure to 1 mumol/L ACh elicited a rebound stimulation of ICa, L in both SAN (33 +/- 4%) and LAP (50 +/- 6%) cells above control.”
“High ACh concentrations were required to inhibit ICa, L only partially (31% inhibition at 300 microM).”
“ ACh (1 mumol/L) decreased basal ICa, L (-19 +/- 2%).”
“We conclude that methionine and leucine enkephalins inhibit the release of acetylcholine from the postganglionic parasympathetic neurons that innervate airway smooth muscle.”
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