Possible Interaction: Acetylcholine and Iodine

“ Acetylcholine induced a higher degree of vasoconstriction (A4, 42 ± 39%; A2, 16 ± 14%) than the rest of the agonists (S, 6 ± 12%; I , 6 ± 11%; P<.01).”

“Activity of acetylcholine esterase (ACHE) increased and content of acetylcholine decreased in the hippocampus of filial mice at age of 30 days with high-dose iodine.”

“4 Thus, in the rat model, ACh is able to stimulate potent endogenous protective mechanisms during I and R, which are evident both at the level of myocardial and coronary endothelial cells, and appear entirely mediated through the production of NO.”

“ I and R induced a significant … of isolated coronary arteries to ACh (maximal response: sham: 58 ± 4; I/R: 25 ± 5%; P < 0.01) and this dysfunction was prevented by prior … ± 7%; P < 0.01 vs I/R) or (SIN‐1 50 ± 5%; P < 0.05 vs I/R).”

“In contrast to the direct muscarinic activation of K+ channel, ACh decreases I Ca by inhibiting, via Ni, the cAMP production.”

“In voltage clamp experiments, ACh markedly reduced the slow inward current and the I Ca -dependent component of contraction for short depolarizing pulses (less than 100 ms) without affecting time-to-peak tension.”