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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Acetylcholine
supplement:
Idebenone
Research Papers that Mention the Interaction
“Catecholamine secretion evoked by acetylcholine was markedly inhibited by idebenone , and this effect was concentration-dependent.”
“ Idebenone also inhibited the radioactive Ca2+ uptake stimulated by acetylcholine or high K+ under the conditions in which its inhibitory action on the secretion was observed.”
Idebenone inhibits catecholamine secretion through its blocking action on Ca2+ channels in cultured adrenal chromaffin cells.“These results indicate that idebenone inhibits the alteration of the ACh level and the disruption of membrane phospholipids in the brain of ischemic rats; these effects may be mediated by improved cerebral energy metabolism.”
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