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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Hydroxocobalamin
Research Papers that Mention the Interaction
“Methylene blue (MB) and hydroxocobalamin (HC) exhibited significant inhibition on the relaxations evoked by EFS, ACh and a-NaNO2.”
An in vitro study of nonadrenergic-noncholinergic activity on the cavernous tissue of mouse“ Hydroxocobalamin , but not carboxy‐PTIO, also inhibited responses to acetylcholine.”
“Hemoglobin, hydroxocobalamin and hydroquinone exhibited significant inhibition on the relaxation evoked by Ach and acidified NaNO2.”
“LY 83583 (6-anilino-5,8-quinolinedione) and hydroxocobalamin clearly inhibited the relaxant responses to electrical field stimulation, acetylcholine , S-nitrosoglutathione and acidified sodium nitrite whereas there was significant enhancement of the relaxation produced by S-nitroso-N-acetyl-D,L-penicillamine.”
“In endothelium-intact preparations, vasodilator responses to acetylcholine (0.3-3 microM) were significantly reduced or abolished by hydroxocobalamin (30-300 microM).”
“The mean reduction by hydroxocobalamin of relaxations to acetylcholine was significantly greater than that of the equivalent response evoked by nitrergic nerve stimulation.”
“In rat aortic rings, hydroxocobalamin (10–30 μm) produced concentration‐dependent reductions of the relaxant action of nitric oxide (NO) and the endothelium‐dependent, NO‐mediated, relaxant action of acetylcholine.”
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