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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Huperzine A
Research Papers that Mention the Interaction
“The marked elevation of ACh after oral administration of huperzine A (0.5 μmol/kg) and donepezil (5.4 μmol/kg) was associated with a significantly increased release of dopamine (DA) in the mPFC or hippocampus.”
Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats“All compounds are non-covalent and reversible inhibitors of AChE. Addition of (+/-)-HX (0.01 microM), GAL (10 microM) and HPA (0.1 microM) to the superfusion medium decreased the release of the ACh neurotransmitter to a similar extent: 36%, 30% and 34%, respectively (P<0.01).”
“injection, huperzine A (0.25-0.75 micromol/kg), donepezil (2-6 micromol/kg) and rivastigmine (0.75-1.5 micromol/kg) dose-dependently elevated the concentration of acetylcholine.”
“This dose of HUP reduced AChE inhibition to 54% and increase of ACh level to 230 times baseline value.”
“ Huperzine‐A , perfused through the microdialysis probe, produced a maximal increase of ACh levels of 3090% and 7790% at concentrations of 5 and 50 μM. The ACh increase seen at both concentrations lasted at least 6 hr.”
“The study shows that HUP‐A can produce a long‐term inhibition of AChE activity in brain (up to 360 min) and an increase in the ACh levels up to 40% at 60 min.”
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