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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Histidine
Research Papers that Mention the Interaction
“Acetylcholine (10−7-10−6 M) and imidazole derivatives (e.g., histidine 10−4 M ) prevent photoinactivation of heart muscle sensitivity to AC.”
Photoinactivation of cholinergic receptors in frog heart muscle“ Acetylcholine (ACh, 0.3–3 μM) caused concentration‐dependent relaxation (maximum relaxation by 89.7±7.5%, n=4, P<0.05) when applied to endothelium‐intact strips precontracted with His.”
“In the biochemical study, histidine significantly decreased acetylcholine (ACh) levels in the cerebral cortex and diencephalon of mice, and also significantly decreased them in the midbrain at a dose of 500 mg/kg.”
“ L-Histidine also enhanced the excitatory action of L-glutamate, D- and L-aspartate, L-homocysteate and especially that of quisqualate, whereas the actions of acetylcholine , kainate, N-methyl-D-aspartate and D-homocysteate were more commonly reduced.”
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