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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Guanidines
Research Papers that Mention the Interaction
“ Guanidine greatly increased the number of acetylcholine (ACh) quanta released by a single motor nerve action potential.”
Guanidine and neuromuscular transmission. I. Effect on transmitter release occurring spontaneously and in response to single nerve stimuli.“Corticosterone, an inhibitor of OCT subtype 1, 2 and 3 reduced acetylcholine in a concentration‐dependent manner … an IC50 value of 2 μM. Substrates of OCT subtype 1, 2 and 3 (amiloride, cimetidine, guanidine , noradrenaline, verapamil) inhibited acetylcholine release , whereas carnitine, a substrate of subtype OCTN2, exerted no effect.”
“ Guanidine was given because it enhances the release of acetylcholine at the neuromuscular junction.”
“SummaryCatechol, guanidine , noradrenaline, and phencyclidine can increase acetylcholine release at neuromuscular junctions.”
Effects of the facilitatory compounds catechol, guanidine, noradrenaline and phencyclidine on presynaptic currents of mouse motor nerve terminals“4 The guanidino substituted analogues also appeared to block selectively the relaxation response to acetylcholine in the coronary artery, independently of their EDRF‐releasing activity.”
“Daily injection of guanidine , which enhances the release of acetylcholine , rapidly produces a severe myopathy in the soleus muscle of the Sprague-Dawley rat.”
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