Possible Interaction: Acetylcholine and Ginseng

“Further SMS treatment (4 or 8 g/kg) significantly increased the ACh levels in the brain homogenate to a level similar to that observed in THA treatment.”

“It is possible that P. ginseng root mediates the release of ACh from nerve terminals to enhance insulin secretion.”

“After 3 months of KRG administration, the relaxation responses to ACh were increased significantly (10(-7) M: 34.18%, 10(-6) M: 56.35%, 10(-5) M: 75.33%, 10(-4) M: 89.86%)(p<0.01).”

“A complex interplay of numerous neurotransmitter systems has been suggested in the pathophysiology of akathisia.4 Studies on Alzheimer disease showed that …, alleviating Ab amyloid-induced cholinergic dysfunction and upregulating the enzymes involved acetylcholine synthesis and release.5,6 Su et al7 reported that ginseng root … acetylcholine from … activity.”

“Briefly, ginseng leads to an increase in the amount and activity of acetylcholine in the central nervous system and may cause akathisia, consequently.”

“The results suggest that ginseng extracts including BGE, appear to modulate the metabolism of acetylchoine (ACh), which would greatly increase synaptic ACh levels and most potently revert SCOP-induced amnesia.”