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Last Updated: 3 months ago

Possible Interaction: Acetylcholine and Ethanol

supplement:

Ethanol

Research Papers that Mention the Interaction

The pharmacodynamic properties of alcohol are diverse, interfering with neuronal membranes, ion channels, enzymes, and receptors in multiple systems including acetylcholine , serotonin, glutamate, and γ-aminobutyric acid (GABA).
Arquivos de neuro-psiquiatria  •  2011  |  View Paper
The potentiation of the maximal currents evoked by high concentrations of acetylcholine suggests that ethanol affects the channel gating.
Alcoholism, clinical and experimental research  •  2004  |  View Paper
Since alcohol has been shown to reduce levels of acetylcholine and contrast sensitivity, the present study measured the effects of alcohol on contrast discrimination and explored whether the deficits could be explained as a consequence of reduction in contrast gain.
Visual neuroscience  •  1999  |  View Paper
IT is known from the work of van Dyke and Ames1 that previously administered ethanol blocks the release of antidiuretic hormone (ADH) in response to acetylcholine.
Nature  •  1963  |  View Paper
In addition, ethanol potentiates distinct nAChR subtype responses to ACh and nicotine in vitro and in DAergic neurons.
Thus, ethanol may increase ACh release into the VTA driving activation of DAergic neurons through nAChRs.
Front. Psychiatry  •  2013  |  View Paper
With chronic use, alcohol can disturb the function and balance of several neurotransmitter systems such as excitatory amino acids, GABA, serotonin, and acetylcholine.
American journal of therapeutics  •  1996  |  View Paper
Ethanol and acetylcholine were also found to increase the resting tension, it being 2 times greater and occurring at a faster rate with acetylcholine.
Pakistan journal of pharmaceutical sciences  •  1989  |  View Paper
Single doses of ethanol caused increased levels of acetylcholine in the brains of fed and fasted rats; heart acetylcholine levels were not affected.
Journal of studies on alcohol  •  1977  |  View Paper
However, the increase in potassium efflux induced by acetylcholine was inhibited by ethanol.
The Journal of general physiology  •  1962  |  View Paper
The possibility may thus be considered that ethanol activates the cholinergic afferents causing a release of acetylcholine in the ventral tegemental area leading to a stimulation of nAChRs and thereby excite the mesocorticolimbic dopamine system.
Neuroscience & Biobehavioral Reviews  •  2004  |  View Paper
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