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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Digitalis
Research Papers that Mention the Interaction
“Since vagal effects on the atrioventricular junction appeared during the later phase, it is suggested that initial action potential prolongation by digitalis may have been effected via local acetylcholine release , while subsequent action potential shortening may have been caused by a combination of vagally and locally mediated activity.”
Observations on the biphasic nature of digitalis electrophysiological actions in the human right atrium.“ Acetylcholine caused slowing of the ventricular rate in five dogs with complete A-V block and ventricular tachycardia produced by digitalis or aeonitine, and reversal to sinus rhythm in two out of three dogs with normal A-V conduction and ventricular tachycardia produced by aconitine.”
Effect of Vagal Stimulation and Acetylcholine on the Ventricle: Studies in Dogs with Complete Atrioventricular Block
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