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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Dietary Fiber
Research Papers that Mention the Interaction
“We can recognize two associated, but separable effects of acetylcholine on skeletal muscle, depolarization of the end-plate producing conducted responses of the muscle, and a more intense depolarization, spreading far beyond the end-plate, producing neuromuscular block and conduction block in the length of the fibre.”
Excitatory and inhibitory effects of the chemical mediators“ Acetylcholine significantly inhibited tone-induced responses of a large proportion of the fibres tested.”
Action of putative neurotransmitters in the guinea pig cochlea“The depolarization elicited by iontophoretically applied acetylcholine ACh ) was reversibly decreased by 20–60% when muscle fibres were exposed to 1–5×10−7 M TPA.”
“Secondly, in contrast to the intracortical connection, some group(s) of fibres , possibly thalamocortical afferents that arise from white matter and terminate in the middle cortical layers are suppressed much less by ACh.”
“ Acetylcholine decreased automaticity in normal fibres only at high concentration (100 microM).”
“In both types of cultures, sensitivity to ionophoretically applied acetylcholine decreased during the period when fibres were growing rapidly and then increased.”
“Since the only known action of the post-synaptic blocking fraction of this venom is due … its affinity to acetylcholine receptors, the results suggest that the spread in the sensitivity of muscle fibres to acetylcholine and their ability to accept a foreign nerve is a consequence of neuromuscular blockade.”
“IT is known that depolarization of the postsynaptic membrane of muscle fibres caused by acetylcholine gradually decreases as a result of its prolonged action: after some time the membrane protential may attain its initial level despite the presence of acetylcholine.”
“It thus seemed likely that externally applied acetylcholine could alter the electrophysiological properties of mammalian C fibres , but with the techniques then used no definite conclusions could be reached.”
“Further they, and later Brown & Gray (1948), also observed that acetylcholine aroused impulses in some of these intestinal fibres.”
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