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Last Updated: 2 years ago

Possible Interaction: Acetylcholine and Dextroamphetamine

Research Papers that Mention the Interaction

In response to d-amphetamine (2.5 mg/kg), acetylcholine increased to 184%, and with a higher dose (5 mg/kg) to 400% of baseline.
Neuroscience Letters  •  2007  |  View Paper
SummaryThe electrically evoked, calcium-dependent release of 3H-acetylcholine from slices of rat striatum was inhibited in a concentration-dependent manner by (+)-amphetamine (0.2–20 μM).
These results support the view that the inhibitory effects of (+)-amphetamine on the electrically-evoked release of 3H-acetylcholine are mediated by dopamine released from a special pool of newly synthetized transmitter rather than through a direct action on an amphetamine recognition site or receptor.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Application of d-amphetamine in the striatum by reverse dialysis elicited a decrease in striatal acetylcholine efflux that could be reversed subsequently by local application ofd-amphetamine in substantia nigra pars reticulata.
The Journal of Neuroscience  •  1997  |  View Paper
These results show that cocaine and d-amphetamine , by increasing dopaminergic transmission, enhance the extracellular concentrations of acetylcholine in both brain areas.
European journal of pharmacology  •  1993  |  View Paper
These results indicate that d-amphetamine increases ACh release in the striatum via a D1 receptor mechanism.
The Journal of pharmacology and experimental therapeutics  •  1991  |  View Paper
The increase in synaptic DA produced by AMPH was reflected by a concentration-dependent reduction in the electrically evoked overflow of [3H]acetylcholine (ACh).
The Journal of pharmacology and experimental therapeutics  •  1986  |  View Paper
AMPH inhibited SE [3H]acetylcholine (ACh) release in a concentration-dependent manner (71% inhibition at 10 microM).
The Journal of pharmacology and experimental therapeutics  •  1986  |  View Paper
(+)-Amphetamine enhances the release of acetylcholine from a nerve-stimulated preparation.
European journal of pharmacology  •  1973  |  View Paper
Dexamphetamine in a dose of 100 mg/kg increased the release of ACh by 1.9 times and had no appreciable effect on the e.e.g.
British journal of pharmacology  •  1968  |  View Paper