Possible Interaction: Acetylcholine and Dextroamphetamine

“In response to d-amphetamine (2.5 mg/kg), acetylcholine increased to 184%, and with a higher dose (5 mg/kg) to 400% of baseline.”

“SummaryThe electrically evoked, calcium-dependent release of 3H-acetylcholine from slices of rat striatum was inhibited in a concentration-dependent manner by (+)-amphetamine (0.2–20 μM).”

“These results support the view that the inhibitory effects of (+)-amphetamine on the electrically-evoked release of 3H-acetylcholine are mediated by dopamine released from a special pool of newly synthetized transmitter rather than through a direct action on an amphetamine recognition site or receptor.”

“Application of d-amphetamine in the striatum by reverse dialysis elicited a decrease in striatal acetylcholine efflux that could be reversed subsequently by local application ofd-amphetamine in substantia nigra pars reticulata.”

“These results show that cocaine and d-amphetamine , by increasing dopaminergic transmission, enhance the extracellular concentrations of acetylcholine in both brain areas.”

“These results indicate that d-amphetamine increases ACh release in the striatum via a D1 receptor mechanism.”

“The increase in synaptic DA produced by AMPH was reflected by a concentration-dependent reduction in the electrically evoked overflow of [3H]acetylcholine (ACh).”

“ AMPH inhibited SE [3H]acetylcholine (ACh) release in a concentration-dependent manner (71% inhibition at 10 microM).”

“ (+)-Amphetamine enhances the release of acetylcholine from a nerve-stimulated preparation.”

“ Dexamphetamine in a dose of 100 mg/kg increased the release of ACh by 1.9 times and had no appreciable effect on the e.e.g.”