Possible Interaction: Acetylcholine and Daidzein

“At low doses, daidzein was found to stimulate catecholamine synthesis through extracellular signal-regulated kinase 1/2 or protein kinase A pathways, but at high doses, it inhibited catecholamine synthesis and secretion induced by acetylcholine.”

“ Daidzein as well as nobiletin (≥ 1.0 μM) inhibited catecholamine synthesis and secretion induced by acetylcholine , a physiological secretagogue.”

“When functional channels were expressed with human alpha4 and beta2 subunits, daidzein (10 and 100 microM) partially inhibited the ionic current activated by acetylcholine.”

“ Daidzein also inhibited the contractility of JSMF induced by ACh , histamine, erythromycin and high Ca2+, respectively, and decreased charcoal propulsion in the small intestine in vivo.”

“ Daidzein at high concentrations (1-100 microm) suppressed catecholamine secretion induced by acetylcholine.”

“…,daidzein , or 17β-… to acetylcholine and decreased the endothelium-dependent vasoconstrictor responses to acetylcholine in SHR, but not in WKY, and these effects were not modified by … 182,780 (7α,17β-[9[(4,4,5,5,5-pentafluoropentyl)-sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol).”

“RESULTS It has been found that da dzein co uld remarkedly antagonize the gall bladder constriction of guinea pig induced by aci tylcholine, h istamine, excessive K+, cumulation Ca2+.”