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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Acetylcholine
supplement:
Cobaltous Cation
Research Papers that Mention the Interaction
“The transition metal ions Co2+ , Mn2+, and Ni2+, but not the nontransition ions (Cd2+, Sn2+ and Zn2+, markedly inhibited ACh and histamine relaxations in the aorta, whereas all metal ions antagonized KCI contractions.”
Effects of Some Inorganic Divalent Cations and Protein Kinase C Inhibitors on Endothelium‐Dependent Relaxation in Rat Isolated Aorta and Mesenteric Arteries“is was suppressed … completely by 2 mM‐Co2+ , is obtained by subtracting the current remaining in 2 mM‐Co2+ … also diminished to the same extent by 2 x 10(‐6) M‐Ach with little change in its time course; the degree … decrease was not dependent on the membrane potential.”
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