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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Choline Chloride
Research Papers that Mention the Interaction
“Precursorloading with choline chloride may increase brain acetylcholine levels and central cholinergic activity.”
Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis.“The ACh produced from the transduced fibroblasts was found to be enhanced by increasing amounts of choline chloride in the culture media.”
In Vivo Production and Release of Acetylcholine from Primary Fibroblasts Genetically Modified to Express Choline Acetyltransferase“Moreover, intra‐and extracellular levels of ACh could be increased by adding exogenous choline chloride.”
“We found that … potassium-depolarized ACh release from rat … significantly accelerated when choline chloride was added to the incubation medium at concentrations of either 60 or 100 microM. The ACh content of … minces was reduced by prolonged depolarization; this depletion was prevented by incubating minces with choline (100 microM).”
“Abstract Administration of choline chloride (200 μmoles/kg) intravenously to guinea pigs caused an increase in the concentrations of choline and acetylcholine in adrenals, heart, kidneys, lungs, and liver within 2 min.”
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