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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Cd2+
Research Papers that Mention the Interaction
“4 In mouse triangularis sterni preparations, Cd2+ (1–30 μm) depressed the evoked quantal release of acetylcholine.”
Reversal by cysteine of the cadmium‐induced block of skeletal neuromuscular transmission in vitro“ Cd2+ (20‐1000 microM), when added to the external solution, reduced Ins, ACh rapidly and reversibly.”
“The transition metal ions Co2+, Mn2+, and Ni2+, but not the nontransition ions Cd2+ , Sn2+ and Zn2+, markedly inhibited ACh and histamine relaxations in the aorta, whereas all metal ions antagonized KCI contractions.”
“Antagonists of Ca2+ entry (Mg2+, Cd2+ , diltiazem) decreased the sensitivity of acetylcholine release to Ca2+, acting as competitive inhibitors, and reduced the stimulation-induced 45Ca accumulation.”
“Data from conventional electrophysiological recordings from primary pacemaker cells within the rabbit sinoatrial node indicate that Cd2+ (10(-6)-10(-5) M) may selectively inhibit acetylcholine release.”
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