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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Carnitine
Research Papers that Mention the Interaction
“Quinine (1 mM), inhibitor of organic cation transporters, and carnitine (0.1 mM), substrate of the Na+‐dependent carnitine transporter OCTN2, tended to reduce acetylcholine release (by 40%, not significant).”
In vivo release of non‐neuronal acetylcholine from the human skin as measured by dermal microdialysis: effect of botulinum toxin“2 Lower concentrations of palmitoyl carnitine (0.3–30 μm; EC50 1.1 μm), but not Bay K 8644, carnitine or palmitic acid, antagonized the relaxant effects of acetylcholine in rat aorta.”
Interactions of palmitoyl carnitine with the endothelium in rat aorta“We found also that carnitine invariably enhances the contractile responses of the preparation to Ach , and this effect is not modified by indomethacin or lysine acetylsalicylate, but usually abolished by fendiline and flunarizine.”
“It resulted also that carnitine has always increased the entity of the contraction of the preparation treated with Ach and that the raising was abolished by fendiline or verapamil.”
“ Acetylcholine levels in the heads of adult flies bred from larvae fed on diets containing acetyl-β-methylcholine or carnitine were reduced to approximately 30 per cent of the level found in adults bred from larvae fed on diets containing choline.”
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