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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Acetylcholine
supplement:
Cannabinoids
Research Papers that Mention the Interaction
“ Cannabinoids also modulate the actions of vasoactive compounds including acetylcholine , methoxamine, angiotensin II and U46619 (thromboxane mimetic).”
Vascular targets for cannabinoids: animal and human studies“Functional studies have shown that activation of cannabinoid CB(1 ) receptors inhibits the synaptic release of many neurotransmitters such as gamma-aminobutyric acid, glutamate, acetylcholine and monoamines.”
The cannabinoid CB1 receptor is expressed on serotonergic and dopaminergic neurons.“The administration of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and synthetic cannabinoids stimulates acetylcholine (ACh) release in the rat prefrontal cortex (PFCx) and hippocampus as estimated by brain microdialysis.”
“ Cannabinoids can reduce the pre-synaptic release of acetylcholine and other neurotransmitters in the mammalian brain through a retrograde signaling pathway.”
“suggesting that acetylcholine output is tonically inhibited by endogenous cannabinoids.”
“The results confirm previous observations that cannabinoids inhibit acetylcholine release through cannabinoid CB1 receptors, and indicate that no tolerance to this effects develops after a repeated Delta9-THC administration.”
“themselves increased hippocampal acetylcholine release, suggesting that acetylcholine output is tonically inhibited by endogenous cannabinoids.”
“Accumulating evidence suggests that the cannabinoids exert their action to reduce the turnover rate of acetylcholine in the hippocampus by an action in the septum via inhibitory gamma-butyric acid (GABA) containing interneurons.”
“Abstract Recent evidence suggests that the cannabinoids exert their action to reduce the turnover rate of acetylcholine in the hippocampus by an action in the septum via inhibitory gamma-butyric acid containing interneurons.”
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