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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Cannabidiol
Research Papers that Mention the Interaction
“CBG, THCV, CBD and CBDV, but not CBC, at concentration ranging from 10−8 M to 10−4 M, decreased (with similar potency), the contractions induced by acetylcholine without significantly modifying the contractions induced by electrical stimulation.”
Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol“ CBD reversibly inhibited ACh (100 μM)-induced currents with an IC50 value of 11.3 µM. Other phytocannabinoids such as cannabinol and Δ(9)-tetrahydrocannabinol did not affect ACh-induced currents.”
“Altogether, these data demonstrate that CBD increases ACh levels in a brain region related to wake control.”
“Moreover, the time course effects on the contents of ACh were present 5 h post-injection of CBD.”
Systemic Injections of Cannabidiol Enhance Acetylcholine Levels from Basal Forebrain in Rats“ CBD enhanced the maximum vasorelaxation to acetylcholine (ACh) in femoral arteries from ZDF lean rats (P < 0.01) and especially ZDF rats (P < 0.0001).”
“Both … of acetylcholine ; on this preparation CBD was more active than THC, … in acetylcholine output was produced by a concentration of CBD at 4 x 10-7M compared with THC at 1-75 x 10-6M, …% reduction by CBD at 1 27x 10-6M, or THCat 159x 10-5M.”
“In contrast to THC, CBD was without effect … M. In some experiments both THC and CBD … acetylcholine , both compounds being effective at a concentration of 3*18 x 10-7 M. These observations … THC was either without effect, or potentiated the action of acetylcholine on the guinea-pig ileum.”
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