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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Acetylcholine significantly attenuated calcium or hydrogen oxide-induced mitochondrial damage and mitochondrial DNA release.”
α7 Nicotinic Acetylcholine Receptor Signaling Inhibits Inflammasome Activation by Preventing Mitochondrial DNA Release“Application of the neurotransmitters GABA, glutamate and acetylcholine induced depolarizing calcium signal changes in neuronal cells providing evidence for the excitatory effects of these ligand-gated ion channels during maturation in vitro.”
“ Calcium ions stimulated the AcH release from synaptosomes twice as high in tolerant as in intolerant animals.”
“When extracellular Ca(2+) was buffered with EGTA, ACh mobilized intracellular calcium stores and the [Ca(2+)](i) increase was reduced by 2-aminoethoxydiphenyl borate but not by dantrolene, indicating the involvement of inositol triphosphate receptors (InsP(3)R).”
“In the normal LES, ACh causes release of Ca++ from intracellular stores and activation of a calmodulin-dependent pathway.”
“We observed that in a modified Krebs' solution in which …+ ] are about the same as in human plasma, the Ca 2+ … acetylcholine is less and the inhibition of the electrically induced isometric twitch tension of the …, in which the [Ca 2+ ] and [Mg 2+ ] are higher than in vivo .”
“ Acetylcholine produced a further contraction which added to the effect of calcium.”
“In the absence of calcium from the potassium Ringer's solution the acetylcholine responses declined and this decline could be accelerated by frequent stimulations with acetylcholine.”
“Calcium competes with magnesium at the pre-junctional site, and thus, an increase in the calcium concentration leads to an increase in the release of acetylcholine from the presynaptic nerve terminal, thereby reducing the relaxant effect induced by magnesium.”
“Measurements of the changes in the intracellular calcium concentration revealed an increase in calcium due to the application of acetylcholine.”
“This decreases calcium entry into the presynaptic terminal, which prevents binding of vesicles to the presynaptic membrane and acetylcholine release.”
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