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Last Updated: 2 years ago

Possible Interaction: Acetylcholine and Berberine

supplement:

Berberine

Research Papers that Mention the Interaction

Both CCF and berberine suppressed the cellular calcium influx and ROCK-1 expression upon ACh stimulation, demonstrating that berberine was one of the active compounds that contributed to CCF-improved micturition symptoms and function.
Journal of ethnopharmacology  •  2020  |  View Paper
Extracts of ZJW and RC and berberine , palmatine and jatrorrhizine, components of RC, all inhibited CA secretion and rise in [Ca(2+)](i) induced by acetylcholine ( ACh ), veratridine (Ver) and/or 56 mM K(+).
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2010  |  View Paper
On the other hand, berberine as well as PAP exhibited a noncompetitive inhibition of the contractile response induced by ACh , whereas ATR showed a competitive inhibition.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1993  |  View Paper
The results suggest that berberine increases ileal contractility by: 1) increasing acetylcholine release from the postganglionic parasympathetic nerve terminal, 2) increasing acetylcholine retention through an inhibition of cholinesterase activity, and 3) blocking alpha 2-adrenoceptors, possibly in the postganglionic parasympathetic nerve.
Life sciences  •  1993  |  View Paper
At higher concentration, berberine (1 x 10(-4) M) facilitated a rightward shift of the dose-response curve of acetylcholine with a reduction of maximum response, indicating that the interactions of the two agents changed from competitive to noncompetitive antagonism.
Lower concentrations of berberine (less than or equal to 5 x 10(-5) M) induced a parallel rightward shift of the dose-response curve of acetylcholine , suggesting that berberine is antagonizing the actions of acetylcholine at the receptors competitively.
Archives internationales de pharmacodynamie et de therapie  •  1991  |  View Paper
The contraction induced by acetylcholine was competitively inhibited by atropine (PA2 = 8.7), whereas berberine , which differs basically from atropine, shifted the dose-response curve for acetylcholine non-parallelly to the right with its maximal response reduced concomitantly.
The effects of phenylephrine and acetylcholine were blocked by berberine as well as by atropine.
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao  •  1989  |  View Paper
The contraction induced by acetylcholine was competitively inhibited by atropine (PA2 = 8.7), whereas berberine , which differs basically from atropine, shifted the dose-response curve for acetylcholine non-parallelly to the right with its maximal response reduced concomitantly.
The effects of phenylephrine and acetylcholine were blocked by berberine as well as by atropine.
Yao xue xue bao = Acta pharmaceutica Sinica  •  1987  |  View Paper
Treatment with berberine inhibited acetylcholinesterase activity, and upregulated acetylcholine levels in the serum and alpha7 nicotinic acetylcholine receptor gene expression in the liver tissue.
Planta medica  •  2021  |  View Paper
Additionally, acetylcholine levels were enhanced after berberine treatment in diabetic rats.
Front. Pharmacol.  •  2019  |  View Paper
Application of Ber reversed the APD shortening induced by ACh (APD50: 81 ± 10 vs. 134 ± 15 msec; APD90: 132 ± 13 vs: 213 ± 17 msec, both P<0.01).
The induced rate of sustained 1 min AF was lower during ACh infusion with Ber than during ACh infusion alone (4/10 vs. 30/35, P<0.01).
American journal of translational research  •  2015  |  View Paper