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Last Updated: 2 years ago

Possible Interaction: Acetylcholine and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

L-NMMA and ADMA inhibited endothelium-dependent relaxation induced by acetylcholine in a concentration-dependent manner; AG and MG were without effect.
Stroke  •  1999  |  View Paper
Femoral arteries (n=7) and renal arteries (n=7) were more … to ADMA than were coronary arteries, and they demonstrated significant ADMA inhibition to receptor … relaxation induced by acetylcholine (P=.03 and P=.01, respectively) and to receptor-independent … induced by calcium ionophore (P=.02 and P=.01, respectively).
Medical science monitor : international medical journal of experimental and clinical research  •  2009  |  View Paper
ADMA (100 &mgr;mol/L) impaired the vascular response to acetylcholine in both non-Tg and DDAH-1–Tg mice, but the relative difference between the 2 strains remained.
In vivo, ADMA (10 &mgr;mol/L) reduced responses of the cerebral arterioles to acetylcholine by ≈70% in non-Tg mice (P<0.05), and this inhibitory effect was largely absent in DDAH-1–Tg mice.
Stroke  •  2008  |  View Paper
Similar effects were observed in isolated vessels where 5 μm ADMA inhibited vascular relaxation to acetylcholine.
Journal of Biological Chemistry  •  2007  |  View Paper
significantly attenuated the inhibition of vasodilator response to acetylcholine and the decreased serum nitrite/nitrate level, and reduced the elevated levels of ADMA , MDA, and TNF-alpha.
Canadian journal of physiology and pharmacology  •  2006  |  View Paper
There was a strong correlation between plasma ADMA and homocyst(e)ine and a strong inverse correlation between ADMA and carotid artery relaxation to acetylcholine.
Arteriosclerosis, thrombosis, and vascular biology  •  2000  |  View Paper
RESULTS Maximal relaxation induced by ac tylcholine wa s significantly attenuated by asy mmetric dimethylarginine (1 2.7% ± 2.3% vs 35.3% ± 5.0% in control; P < .05) and significantly restored by AVE3085 (23.4% ± 2.8%; P < .05).
The Journal of thoracic and cardiovascular surgery  •  2012  |  View Paper
The inhibitors of nitric oxide synthase … NG,NG-dimethyl-l-arginine ADMA ) reduced … to acetylcholine in veins from controls and non-dialysed patients; the remaining relaxation was inhibited by 20 mmol/l … tetraethylammonium chloride, iberiotoxin, charybdotoxin and the combination of barium plus ouabain, but not by apamin or glibenclamide.
Journal of hypertension  •  2003  |  View Paper
When the efficacy of acetylcholine was reduced by phenoxybenzamine, its residual relaxant effect was powerfully inhibited by L-NMMA or ADMA (0.1 or 1mM).
European journal of pharmacology  •  2014  |  View Paper
In contrast, the NO synthase inhibitor, asymmetric dimethyl l-arginine , reduced the NO concentration and acetylcholine relaxation , while these responses were abolished in the presence of oxyhaemoglobin.
Journal of hypertension  •  2002  |  View Paper
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