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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“L-NMMA and ADMA inhibited endothelium-dependent relaxation induced by acetylcholine in a concentration-dependent manner; AG and MG were without effect.”
Effects of some guanidino compounds on human cerebral arteries.“Femoral arteries (n=7) and renal arteries (n=7) were more … to ADMA than were coronary arteries, and they demonstrated significant ADMA inhibition to receptor … relaxation induced by acetylcholine (P=.03 and P=.01, respectively) and to receptor-independent … induced by calcium ionophore (P=.02 and P=.01, respectively).”
“ ADMA (100 &mgr;mol/L) impaired the vascular response to acetylcholine in both non-Tg and DDAH-1–Tg mice, but the relative difference between the 2 strains remained.”
“In vivo, ADMA (10 &mgr;mol/L) reduced responses of the cerebral arterioles to acetylcholine by ≈70% in non-Tg mice (P<0.05), and this inhibitory effect was largely absent in DDAH-1–Tg mice.”
“Similar effects were observed in isolated vessels where 5 μm ADMA inhibited vascular relaxation to acetylcholine.”
“significantly attenuated the inhibition of vasodilator response to acetylcholine and the decreased serum nitrite/nitrate level, and reduced the elevated levels of ADMA , MDA, and TNF-alpha.”
“There was a strong correlation between plasma ADMA and homocyst(e)ine and a strong inverse correlation between ADMA and carotid artery relaxation to acetylcholine.”
“RESULTS Maximal relaxation induced by ac tylcholine wa s significantly attenuated by asy mmetric dimethylarginine (1 2.7% ± 2.3% vs 35.3% ± 5.0% in control; P < .05) and significantly restored by AVE3085 (23.4% ± 2.8%; P < .05).”
“The inhibitors of nitric oxide synthase … NG,NG-dimethyl-l-arginine ADMA ) reduced … to acetylcholine in veins from controls and non-dialysed patients; the remaining relaxation was inhibited by 20 mmol/l … tetraethylammonium chloride, iberiotoxin, charybdotoxin and the combination of barium plus ouabain, but not by apamin or glibenclamide.”
“When the efficacy of acetylcholine was reduced by phenoxybenzamine, its residual relaxant effect was powerfully inhibited by L-NMMA or ADMA (0.1 or 1mM).”
The ability of asymmetric dimethylarginine (ADMA) or monomethylarginine (L-NMMA) to block endothelium-dependent, nitric oxide-mediated relaxation in rat aorta is inversely related to the efficacy of the relaxant stimulus.“In contrast, the NO synthase inhibitor, asymmetric dimethyl l-arginine , reduced the NO concentration and acetylcholine relaxation , while these responses were abolished in the presence of oxyhaemoglobin.”
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