Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Acetylcholine and Aspartic Acid

Research Papers that Mention the Interaction

There are seven BoNT serotypes (A,B,CI D ,E,F, and G), all of which inhibit acetylcholine release , though their intracellular target proteins, the characteristics of their actions, and their potencies vary substantially.
Medicinski arhiv  •  2008  |  View Paper
A … D for binding to two sites at a receptor reveal that the potencies of muscle relaxants, defined by IC50, and the slopes of the NMB … sites, (2) the orientation of the affinities relative to those of A, and (3) the affinities of A for the same two sites.
Journal of Pharmacokinetics and Pharmacodynamics  •  2003  |  View Paper
BACKGROUND & AIMS In esophageal circular muscle, acetylcholine activates phosphatidylcholine-specific phospholipases C and D and phospholipase A2, producing diacylglycerol and arachidonic acid, which cause contraction by interacting synergistically to activate protein kinase C. In a model of acute esophagitis, leukotriene D4 (LTD4) contributes to acetylcholine-induced contraction.
Gastroenterology  •  1998  |  View Paper
The results presented … that in D neurons of the … Helix pomatia L., acetylcholine (ACh) (10 divided by 100 microM) and serotonin (5-HT) (0.1 divided by 1000 microM) applications reduce both the basal intracellular concentration level ([Ca2+]in) and the amplitudes of calcium transients induced by membrane depolarization.
Cellular signalling  •  1994  |  View Paper
D ,L-PCA 500 and 1000 mg/kg also prevented the decrease in brain ACh level.
Pharmacological research communications  •  1987  |  View Paper
The ganglion stimulant effects of DMPP and acetylcholine were only antagonised by the higher doses of d- and d ,l-propranolol.
European journal of pharmacology  •  1975  |  View Paper