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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Aspartic Acid
Research Papers that Mention the Interaction
“There are seven BoNT serotypes (A,B,CI D ,E,F, and G), all of which inhibit acetylcholine release , though their intracellular target proteins, the characteristics of their actions, and their potencies vary substantially.”
[Mechanism of therapy effects by botulinum neurotoxin].“An increase in the degree of synchrony of ACh quantal release, such as that produced by Glu, was obtained after application of N‐methyl‐D‐aspartic acid (NMDA).”
Metabotropic and ionotropic glutamate receptors mediate the modulation of acetylcholine release at the frog neuromuscular junction“The function of phrenic diaphragm in Group B, C and D were gradually decreased after ACh was added into the container.”
“BACKGROUND & AIMS In esophageal circular muscle, acetylcholine activates phosphatidylcholine-specific phospholipases C and D and phospholipase A2, producing diacylglycerol and arachidonic acid, which cause contraction by interacting synergistically to activate protein kinase C. In a model of acute esophagitis, leukotriene D4 (LTD4) contributes to acetylcholine-induced contraction.”
“Endothelium-dependent vasodilator responses to acetylcholine were significantly depressed in both diabetic groups ( D and D + U, p < 0.01 versus control), and there were no differences between the two diabetic groups.”
“ ACh evoked contractures are also inhibited by diltiazem ( D ); washout of D is immediately followed by recovery.”
“The … of Asp to Asn decreased the affinity of the receptor for ACh 100-fold, whereas the mutation of either Asp, Glu, or 8 other acidic residues in the same region of decreased the affinity by 3-fold or less (Czajkowski, C., Kaufmann, C., and Karlin, A.(1993) Proc.”
“The results presented … that in D neurons of the … Helix pomatia L., acetylcholine (ACh) (10 divided by 100 microM) and serotonin (5-HT) (0.1 divided by 1000 microM) applications reduce both the basal intracellular concentration level ([Ca2+]in) and the amplitudes of calcium transients induced by membrane depolarization.”
“At higher concentrations, D 600 (25 μM) or nifedipine (2 μM) practically abolished the ionic and secretory effects of 1 μM ACh.”
“Both glucose and ACh induced 45Ca uptake were inhibited by D 600.”
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